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In connective tissue, ZIP7 deficiency impairs protein disulfide isomerase function, leading to defective ER-folding capacity and disrupted development of the dermis, bone and teeth, as demonstrated in connective-tissue-specific ZIP7-knockout mice 69

PMID: 27,812,975

Week 1 to 4: The Adjustment Phase During the first few weeks, your healthcare provider will usually start you on a low dose to minimize side effects like nausea or stomach upset

doi: 10.1016/j.ijbiomac.2024.136843, 135

Thus, peripheral taste-pathway modulation should be interpreted as one biologically plausible component of altered eating experience, but not as a sufficient explanation for the full human phenotype